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nan3
Education
What is PIMS?
Imprinted Gene Diseases
Clinical Studies
PIMS lab process
Home- Education- What is PIMS?-
NEW ERA of IVF
Challenges for Current IVF Industry
  • IVF successful rate: live birth per embryo transfer
  • The real challenge: how to reduce miscarriage rate
  • Even more challenging.... is our offspring healthy?
What is PIMS ...the latest PGT technology

Preimplantation Methylation Screening (PIMS) is a groundbreaking and innovative embryo screening technology that can test both chromosomal aneuploidy and DNA methylomes including whole-genome methylation level, DMRs (Differential Methylation Regions), and imprinted genes


The first and only technology in the world that can test both molecular genetics and epigenetics information from an embryo within a single PIMS run

Difference between PGT-A and PIMS
PGT-A
Biopsy 3-5 TE Cells from D5 blastocysts
Next Generation sequencing(NGS)
Results
• Copied number variations(CNV)
PIMS
Biopsy 3-5 TE Cells from D5 blastocysts
Micro Enzymatic Methyl-seq(MEM-seg)
Results
• Copied number variations(CNV)
• lmprinted genes
• Methylation level
• Al analysis
How does PIMS work?
Chromosomal Aneuploidy
Chromosomal Aneuploidy
Check if the embryos are euploid (normal), mosaic (partially abnormal) or aneuploid (abnormal)
Methylation Level
Methylation Level
Test the methylation level to determine if embryos fall into the optimal range
Imprinted Gene Diseases
Imprinted Gene Diseases
Test the methylation status of the specific imprinted genes to determine the risks of obtaining related diseases
AI Analysis for Embryo Selection
AI Analysis for Embryo Selection
Analyze all the parameters by using proprietary AI algorithm to predict which embryo has the best potential

Technology Advantage


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